{"id":20145,"date":"2023-02-14T08:05:22","date_gmt":"2023-02-14T08:05:22","guid":{"rendered":"https:\/\/msdconecta.co.cr\/es\/?page_id=20145"},"modified":"2023-09-28T13:00:59","modified_gmt":"2023-09-28T13:00:59","slug":"infografia-prevymis-wp-0220","status":"publish","type":"page","link":"https:\/\/msdconecta.co.cr\/es\/infografia-prevymis-wp-0220\/","title":{"rendered":"INFOGRAF\u00cdA PREVYMIS"},"content":{"rendered":"
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\n \n\n\n \n \n \n 1. Todos los receptores seropositivos a CMV (R+) tienen un alto riesgo de reactivaci\u00f3n del citomegalovirus. <\/span>\n \n \n\n \n \n <\/use>\n<\/svg>\n <\/span>\n <\/button>\n <\/h4>\n \n
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Se ha demostrado que la infecci\u00f3n por CMV se presenta despu\u00e9s del trasplante de c\u00e9lulas madre hematopoy\u00e9ticas (TCMH) alog\u00e9nico en aproximadamente 60% a 80% de los pacientes seropositivos a CMV sin profilaxis.3,4<\/sup><\/p>\n\n\n\n

Todos los receptores seropositivos a CMV (R+) tienen un alto riesgo de reactivaci\u00f3n del citomegalovirus. 1<\/sup><\/p>\n\n <\/div>\n <\/div>\n<\/section>\n\n\n\n\n \n \n \n 2. Cualquier nivel de viremia por citomegalovirus se ha asociado con un mayor riesgo de mortalidad durante el primer a\u00f1o despu\u00e9s del trasplante. <\/span>\n \n \n\n \n \n <\/use>\n<\/svg>\n <\/span>\n <\/button>\n <\/h4>\n \n

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Los pacientes con TCMH con cualquier viremia positiva tuvieron 2.6 veces mayor riesgo de mortalidad global que los pacientes sin viremia hasta los 60 d\u00edas despu\u00e9s del TCMH.2<\/sup><\/strong><\/p>\n\n\n\n

Carga viral de CMV como un factor de riesgo de mortalidad dependiente del tiempo durante 1 a\u00f1o despu\u00e9s de un TCMH (n=926)2,a<\/sup>

Cualquier nivel de viremia por citomegalovirus se ha asociado con un mayor riesgo de mortalidad durante el primer a\u00f1o despu\u00e9s del trasplante.2<\/sup> <\/p>\n\n\n\n

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  • Resultados de un amplio estudio de cohortes observacional y retrospectivo de mediciones recopiladas previamente sobre viremia por CMV y resultados cl\u00ednicos (N=1037)2<\/sup><\/li><\/ul>\n\n\n\n

    IC = intervalo de confianza
    a<\/sup> La carga viral fue una variable de umbral. Los datos se evaluaron usando un modelo de riesgo proporcional multivariables de Cox.2<\/sup><\/p>\n\n <\/div>\n <\/div>\n<\/section>\n\n\n\n\n \n \n \n 3. Se ha demostrado que la reactivaci\u00f3n del citomegalovirus ocurre poco despu\u00e9s del trasplante. <\/span>\n \n \n\n \n \n <\/use>\n<\/svg>\n <\/span>\n <\/button>\n <\/h4>\n \n

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    M\u00e1s del 30% de los pacientes con TCMH que eran seropositivos a CMV o ten\u00edan un donante seropositivo presentaron infecci\u00f3n por CMV durante 1 mes despu\u00e9s del trasplante.2<\/sup><\/strong><\/p>\n\n\n\n

    Incidencia de reactivaci\u00f3n de CMV en pacientes con TCMH seropositivos a CMV o con un donante seropositivo a lo largo de 12 meses despu\u00e9s del trasplante.2<\/sup><\/p>\n\n\n\n

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    Resultados de un amplio estudio de cohortes observacional y retrospectivo de mediciones recopiladas previamente sobre viremia por CMV y resultados cl\u00ednicos (N = 1037)2<\/sup><\/p>\n\n\n\n

    Se ha demostrado que la reactivaci\u00f3n del citomegalovirus ocurre poco despu\u00e9s del trasplante. 2<\/sup><\/p>\n\n <\/div>\n <\/div>\n<\/section>\n\n<\/div>\n\n\n\n

    <\/div>\n\n\n\n

    Referencias<\/strong>
    1. George B, Pati N, Gilroy N, y cols. Pre-transplant cytomegalovirus (CMV) serostatus remains the most important determinant of CMV reactivation after allogeneic hematopoietic stem cell transplantation in the era of surveillance and preemptive therapy. Transpl Infect Dis. 2010;12(4):322-329
    2. Green ML, Leisenring W, Xie H, y cols. Cytomegalovirus viral load and mortality after haematopoietic stem cell transplantation in the era of pre-emptive therapy: a retrospective cohort study. Lancet Haematol. 2016;3:e119-e127.
    3. Ljungman P, Hakki M, Boeckh M. Cytomegalovirus in hematopoietic stem cell transplant recipients. Hematol Oncol Clin North Am. 2011;25(1):151-169.
    4. Sousa H, Boutolleau D. Ribeiro J, y cols. Cytomegalovirus infection in patients who underwent allogeneic hematopoietic stem cell transplantation in Portugal: a five-year retrospective review. Biol Blood Marrow. 2014;20(12):1958-1967.<\/p>\n\n\n\n

    Para Uso Exclusivo del profesional m\u00e9dico
    <\/strong>01-25 CD-CYT-00001<\/p>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n\n\n

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