{"id":86675,"date":"2024-01-04T11:21:04","date_gmt":"2024-01-04T11:21:04","guid":{"rendered":"https:\/\/msdconecta.co.cr\/es\/?page_id=86675"},"modified":"2024-01-05T12:11:32","modified_gmt":"2024-01-05T12:11:32","slug":"dosis-de-la-magnitud-e-impacto-del-cmv-en-el-marco-del-tcmh-wp-0524","status":"publish","type":"page","link":"https:\/\/msdconecta.co.cr\/es\/dosis-de-la-magnitud-e-impacto-del-cmv-en-el-marco-del-tcmh-wp-0524\/","title":{"rendered":"Dosis de la magnitud e impacto del CMV en el marco del TCMH"},"content":{"rendered":"
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Dosis de la magnitud e impacto del CMV en el marco del TCMH<\/h3>\n\n\n
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<\/p>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n\n

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Consecuencias de la Reactivaci\u00f3n CMV<\/span><\/strong><\/h3>\n\n\n
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Se puede producir Neutropenia e IRA con el uso de antivirales.7<\/sup><\/p>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n\n

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Enfermedad GI y\/o EICH gastrointestinal.6<\/sup><\/p>\n\n\n\n

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Incremento de mortalidad.6<\/sup><\/p>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n<\/div>\n\n\n

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Riesgo de disfunci\u00f3n de \u00f3rgano.7<\/sup><\/p>\n\n\n\n

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Diversos puntos de corte de carga viral no establecidos.8<\/sup><\/p>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n\n

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Posibilidad de infecciones f\u00fangicas.7<\/sup><\/p>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n<\/div>\n\n\n

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Incremento de los costos, mayor n\u00famero de hospitalizaci\u00f3n y readmisiones.10<\/sup><\/p>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n\n\n

IRA: Infecci\u00f3n respiratoria aguda
GI:Gastrointestinal
TCMH: Trasplante helog\u00e9nico de c\u00e9lulas madre hematopoyetivas
EICH: Enfermedad de injerto contra el hu\u00e9sped.<\/p>\n\n\n

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Impacto cl\u00ednico:
Enfermedad
por CMV y
mortalidad no
relacionada<\/strong><\/p>\n\n<\/div>\n\n\n

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Los pacientes con CMV+ tuvieron una mortalidad no relacionada del 34.9% vs un 10.5% de los pacientes que no tuvieron CMV.10<\/sup>



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Los pacientes CMV+ que desarrollaron enfermedad neum\u00f3nica tuvieron una mortalidad no relacionada del 42.2% vs un 12.5% de los que no tuvieron CMV.<\/p>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n\n\n

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Referencias:<\/strong>

1. Lunjgman P. Lancet Infect Dis 2019; 19 (8): e-260-e272
2. Odzemir E. Bone Marr TRansplant 2007; 40: 125-136Boeckh
3. M. Blood 2009; 113 (23): 5711-5719
4. Hakki M. Transplantation and celular therapy 2021:27:707-719
5. Pande A. Infect Dis Clin N Am 2019; 33(2): 485-500
6. Young M. Biol Blood Marrow Transplant 2017; 23(11):1961-1967
7. Zavras P. Biology of Blood and Marrow TRansplantation 2020; 26(8): 1489-1491 Fang J. Biology of Blood and Marrow Transplantation 2020; 26(10=: 1937-1947
8. Limaye A. Cin Microbiol Rev 2021; 34 (1):e00043-19 Byung-Sik C. Ann Hematol 2013; 94: 4
9. Pande A. Infect Dis Clin N Am 2019: 33(2):485-500Lujngman P. Lancet Infect Dis 2019; 19(8):e-260-e2720
10. MENG X-Y ANN HEMATOL, 2020-99(11): 2659<\/mark><\/p>\n\n\n\n

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Para uso exclusivo de profesional m\u00e9dico<\/strong><\/p>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n<\/div>\n\n <\/div>\n\n 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