{"id":92007,"date":"2024-08-21T11:32:04","date_gmt":"2024-08-21T11:32:04","guid":{"rendered":"https:\/\/msdconecta.co.cr\/es\/?page_id=92007"},"modified":"2024-09-05T16:06:29","modified_gmt":"2024-09-05T16:06:29","slug":"prevencion-de-la-enfermedadpor-cmv-en-receptores-de-trasplantede-rinon-d-r-de-alto-riesgo-wp-0679","status":"publish","type":"page","link":"https:\/\/msdconecta.co.cr\/es\/prevencion-de-la-enfermedadpor-cmv-en-receptores-de-trasplantede-rinon-d-r-de-alto-riesgo-wp-0679\/","title":{"rendered":"Prevenci\u00f3n de la enfermedadpor CMV en receptores de trasplantede ri\u00f1\u00f3n D+\/R- de alto riesgo"},"content":{"rendered":"<div class=\"mhh-mcn-columns mhh-mcn-columns--align-medium mhh-mcn-v1-columns--b4b85f3406a52435a14a1998ee3cec98 mhh-mcn-v1-columns mhh-mcn-columns--gutter-m\">\n    <div class=\"mhh-mcn-columns-inner\">\n        \n<div class=\"mhh-mcn-v1-column mhh-mcn-v1-column--290e69aba3c4bc64845922cd0a7d5bdb mhh-mcn-column mhh-mcn-column--12 mhh-mcn-column--m-12 mhh-mcn-column--l-12\">\n    \n\n<h2 dir=\"ltr\" lang=\"es-CO\" class=\"wp-block-heading has-text-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--f669fec868d2153e65190737e04b982f\" style=\"color:#4f758b\"><strong>Prevenci\u00f3n de la enfermedad por CMV en receptores de trasplante de ri\u00f1\u00f3n D+\/R- de alto riesgo<sup>1,2<\/sup><\/strong><\/h2>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-alert-green-color has-alpha-channel-opacity has-alert-green-background-color has-background\" \/>\n\n\n\n<p class=\"   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--58f74267b269436079e2787ef0ad7187\" dir=\"ltr\" lang=\"es-CO\"><strong>Dise\u00f1o del estudio: <\/strong>ensayo cl\u00ednico fase 3, multic\u00e9ntrico, doble ciego, controlado por comparador activo, de no inferioridad en pacientes adultos con trasplante de ri\u00f1\u00f3n de alto riesgo (D+\/R-) que recibieron PREVYMIS junto con aciclovir una vez al d\u00eda versus valganciclovir junto con un placebo frente a aciclovir (N=589). La profilaxis se inici\u00f3 desde el d\u00eda 0 al 7 y se continu\u00f3 hasta la semana 28 (~200 d\u00edas) post-trasplante. El criterio de valoraci\u00f3n principal de eficacia fue la incidencia de enfermedad por CMV (enfermedad por CMV de \u00f3rganos terminales o s\u00edndrome CMV, confirmado por un comit\u00e9 de adjudicaci\u00f3n independiente) hasta la semana 52 despu\u00e9s del trasplante.<sup>3<\/sup><\/p>\n\n\n\n<div style=\"height:48px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 dir=\"ltr\" lang=\"es-CO\" class=\"wp-block-heading has-text-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--cc5302362fea5acf092c8053093741c4\" style=\"color:#92278f\"><strong>PREVYMIS fue no inferior a valganciclovir en la prevenci\u00f3n de la enfermedad por CMV postrasplante (criterio de valoraci\u00f3n principal)<sup>3<\/sup><\/strong><\/h3>\n\n\n\n<h4 dir=\"ltr\" lang=\"es-CO\" class=\"wp-block-heading has-text-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--6bbc932959f481eaa785b5f8400b91e3\" style=\"color:#4f758b\"><strong>Porcentaje de pacientes con enfermedad por CMV hasta la semana 52 despu\u00e9s del trasplante (enfoque de falla observada [OF])<sup>3<\/sup><\/strong><\/h4>\n\n\n<figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--7a81c82b189b0dbbdba1771b2a28ad34\">\n                    <img loading=\"lazy\" decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--full wp-image-92018\"\n        src=\"https:\/\/msdconecta.co.cr\/es\/wp-content\/uploads\/sites\/77\/2024\/08\/cuadro.png?quality=80&#038;lossy=1\"\n        width=\"1024\"\n        height=\"264\"\n                alt=\"\"\n            \/>\n            <\/figure>\n\n\n\n<p dir=\"ltr\" lang=\"es-CO\" class=\"has-object-object-font-size   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--d7da033d6d20a12bac8fd2e5606b8191\"><sup>a<\/sup>Casos de enfermedad por CMV confirmados por un comit\u00e9 de adjudicaci\u00f3n independiente.<sup>3<\/sup><br><sup>b<\/sup>Basado en un margen de no inferioridad del 10 %, PREVYMIS es no inferior a valganciclovir.<sup>3<\/sup><br>Enfoque para el manejo de valores perdidos: enfoque OF. Con el enfoque OF, los sujetos que suspendieron prematuramente el tratamiento en estudio por cualquier motivo no se consideraron fracasos.<sup>3<\/sup><\/p>\n\n\n\n<div style=\"height:48px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 dir=\"ltr\" lang=\"es-CO\" class=\"wp-block-heading has-text-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--169509016d5f2edeaacf0edea979a692\" style=\"color:#92278f\"><strong>Enfermedad por CMV hasta la semana 28 (~200 d\u00edas) despu\u00e9s del trasplante<sup>3<\/sup><\/strong><\/h3>\n\n\n\n<h4 dir=\"ltr\" lang=\"es-CO\" class=\"wp-block-heading has-text-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--6a53a3b8dbb1d02f75976be05f4cbaf3\" style=\"color:#4f758b\"><strong>Pacientes con enfermedad por CMV hasta la semana 28 (~200 d\u00edas) despu\u00e9s del trasplante<sup>3<\/sup><\/strong><\/h4>\n\n\n<figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--70551098a092a27d3e2ed53cd4fbab18\">\n                    <img decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--full wp-image-92030\"\n        src=\"https:\/\/msdconecta.co.cr\/es\/wp-content\/uploads\/sites\/77\/2024\/08\/CMV.png?quality=80&#038;lossy=1\"\n        width=\"1024\"\n        height=\"257\"\n        loading=\"lazy\"        alt=\"\"\n            \/>\n            <\/figure>\n\n\n\n<p dir=\"ltr\" lang=\"es-CO\" class=\"has-object-object-font-size   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--d8bbe066ac66571ae615ac0bcfaa505b\"><sup>c<\/sup>Casos de enfermedad por CMV confirmados por un comit\u00e9 de adjudicaci\u00f3n independiente.<sup>3<\/sup><br><sup>d<\/sup>Resultado secundario de eficacia.<sup>3<\/sup><\/p>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-alert-green-color has-alpha-channel-opacity has-alert-green-background-color has-background\" style=\"margin-top:var(--wp--preset--spacing--60);margin-bottom:var(--wp--preset--spacing--60)\" \/>\n\n\n\n<h3 dir=\"ltr\" lang=\"es-CO\" class=\"wp-block-heading has-text-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--4c7f2ff4f4b7c367adaf37e0ee6a337b\" style=\"color:#92278f\"><strong>An\u00e1lisis post hoc del estudio de fase 3<\/strong><\/h3>\n\n\n\n<p class=\"   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--a337baf716c978b5509c952b554b45e2\" dir=\"ltr\" lang=\"es-CO\">En este estudio de fase 3, doble ciego y controlado con placebo, los pacientes fueron aleatorizados para recibir PREVYMIS 480 mg por v\u00eda oral una vez al d\u00eda 6 y aciclovir 400 mg por v\u00eda oral dos veces al d\u00eda (dosis de aciclovir ajustada para la DepCreat) o valganciclovir 900 mg por v\u00eda oral una vez al d\u00eda (dosis ajustada para DepCreat) con placebo equivalente a aciclovir dos veces al d\u00eda.<sup>3,4<\/sup><\/p>\n\n\n\n<h4 dir=\"ltr\" lang=\"es-CO\" class=\"wp-block-heading has-text-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--1246228c36aed186b984b09077245af6\" style=\"color:#4f758b\"><strong>Limitaciones del an\u00e1lisis post-hoc<sup>4<\/sup><\/strong><\/h4>\n\n\n\n<ul class=\"mhh-mcn-v1-clist mhh-mcn-v1-clist--6ce94c0e477c2fca45cafb5f8db9cb84 mhh-mcn-v1-clist--order-starts-2-digits mhh-mcn-list list-style-type-dot\" dir=\"ltr\" lang=\"es-CO\" start=\"1\">\n    <li>An\u00e1lisis post hoc y de subgrupos.<sup>4<\/sup><\/li><li>El an\u00e1lisis se realiz\u00f3 hasta la semana 28 despu\u00e9s del trasplante de ri\u00f1\u00f3n; sin embargo, el criterio de valoraci\u00f3n principal del estudio se evalu\u00f3 hasta la semana 52.<sup>4<\/sup><\/li><li>El an\u00e1lisis no tuvo la potencia necesaria para mostrar diferencias entre los brazos de profilaxis.<\/li><li>El estudio excluy\u00f3 a pacientes con DepCreat \u226410 ml\/min.<sup>5<\/sup><\/li><\/ul>\n\n\n\n<div style=\"height:48px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 dir=\"ltr\" lang=\"es-CO\" class=\"wp-block-heading has-text-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--3cbb425b294c703acb67916f663b711c\" style=\"color:#4f758b\"><strong>Modificaciones de dosis debido a la DepCreat (&lt;60 ml\/min) hasta la semana 28<sup>4<\/sup><\/strong><\/h4>\n\n\n\n<ul class=\"mhh-mcn-v1-clist mhh-mcn-v1-clist--7b952b7452a70cb83a93c4137060059c mhh-mcn-v1-clist--order-starts-2-digits mhh-mcn-list list-style-type-dot\" dir=\"ltr\" lang=\"es-CO\" start=\"1\">\n    <li><span style=\"background-color: var(--mhh-mcn-clist-background-color, transparent);color: var(--mhh-mcn-clist-text-color, unset);font-size: var(--mhh-mcn-clist-font-size--l, var(--mhh-mcn-font-size--xm));font-family: var(--font-primary)\">El estudio excluy\u00f3 a pacientes con DepCreat \u226410 ml\/min.<sup>5<\/sup><\/span><\/li><\/ul>\n\n\n\n<div style=\"height:48px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--62a8dfab83eeebddaa2336a811cb8aaa\">\n                    <img decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--full wp-image-92044\"\n        src=\"https:\/\/msdconecta.co.cr\/es\/wp-content\/uploads\/sites\/77\/2024\/08\/modificacion-de-dosis.png?quality=80&#038;lossy=1\"\n        width=\"903\"\n        height=\"495\"\n        loading=\"lazy\"        alt=\"\"\n            \/>\n            <\/figure>\n\n\n\n<div style=\"height:48px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 dir=\"ltr\" lang=\"es-CO\" class=\"wp-block-heading has-text-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--167a8998715d4c577e8f8ebc8f1fc211\" style=\"color:#4f758b\"><strong>Incidencia de ADNemia por CMV cuantificable hasta la semana 28 por cuartil de DepCreat<sup> 4,e<\/sup><\/strong><\/h4>\n\n\n\n<ul class=\"mhh-mcn-v1-clist mhh-mcn-v1-clist--1e8428a344395157180262cde37482da mhh-mcn-v1-clist--order-starts-2-digits mhh-mcn-list list-style-type-dot\" dir=\"ltr\" lang=\"es-CO\" start=\"1\">\n    <li>La ADNemia por CMV cuantificable se dividi\u00f3 en cuartiles; Cuartiles: 1 (0 a \u226452 ml\/min), 2 (&gt;52 a \u226467 ml\/min), 3 (&gt;67 a \u226485 ml\/min) y 4 (&gt;85 ml\/min).<sup>4<\/sup><\/li><\/ul>\n\n\n\n<div style=\"height:48px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--dc9705d07b1b1a58fa931ac95807cf99\">\n                    <img decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--full wp-image-92050\"\n        src=\"https:\/\/msdconecta.co.cr\/es\/wp-content\/uploads\/sites\/77\/2024\/08\/ADNemia.png?quality=80&#038;lossy=1\"\n        width=\"862\"\n        height=\"513\"\n        loading=\"lazy\"        alt=\"\"\n            \/>\n            <\/figure>\n\n\n\n<p dir=\"ltr\" lang=\"es-CO\" class=\"has-object-object-font-size   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--ee245409fb8956f9f097e4577fd4637f\"><sup>e<\/sup>No se incluyeron los participantes sin DepCreat en la semana 28.<sup>4<\/sup><\/p>\n\n\n\n<div style=\"height:48px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 dir=\"ltr\" lang=\"es-CO\" class=\"wp-block-heading has-text-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--d85c4133156468f12cefb65341bc094f\" style=\"color:#4f758b\"><strong>Incidencia de enfermedad por CMV (confirmada mediante adjudicaci\u00f3n) hasta la semana 28 por cuartil de DepCreat<sup>4,e<\/sup><\/strong><\/h4>\n\n\n\n<ul class=\"mhh-mcn-v1-clist mhh-mcn-v1-clist--08b0f871b22dee42e4595757724871eb mhh-mcn-v1-clist--order-starts-2-digits mhh-mcn-list list-style-type-dot\" dir=\"ltr\" lang=\"es-CO\" start=\"1\">\n    <li>La enfermedad por CMV cuantificable se dividi\u00f3 en cuartiles; Cuartiles: 1 (0 a \u226452 ml\/min), 2 (&gt;52 a \u226467 ml\/min), 3 (&gt;67 a \u226485 ml\/min) y 4 (&gt;85 ml\/min).<sup>4<\/sup><\/li><\/ul>\n\n\n<figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--8b2666b261ed0a2602d8a2d35e23b69a\">\n                    <img decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--full wp-image-92061\"\n        src=\"https:\/\/msdconecta.co.cr\/es\/wp-content\/uploads\/sites\/77\/2024\/08\/Screenshot_1.png?quality=80&#038;lossy=1\"\n        width=\"869\"\n        height=\"517\"\n        loading=\"lazy\"        alt=\"\"\n            \/>\n            <\/figure>\n\n\n\n<div style=\"height:48px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 dir=\"ltr\" lang=\"es-CO\" class=\"wp-block-heading  has-text-color mhh-mcn-v1-heading--center mhh-mcn-v1-heading mhh-mcn-v1-heading--7b73b71631d91c03c04e60e3a839c05a\" style=\"color:#4f758b;background-color:#e8f7cc\"><strong>Considere la profilaxis contra CMV con PREVYMIS en sus receptores adultos de trasplante de ri\u00f1\u00f3n D+\/R-<sup>2<\/sup><\/strong><\/h3>\n\n\n\n<p dir=\"ltr\" lang=\"es-CO\" class=\"has-object-object-font-size   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--8e3b57114f92a93bf2217a1b423b897f\">IC: intervalo de confianza; CMV, citomegalovirus; DepCreat: depuraci\u00f3n de creatinina; D+\/R-, donante CMV seropositivo\/receptor CMV seronegativo; ADN, \u00e1cido desoxirribonucleico; OF, fallo observado.<\/p>\n\n\n\n<p dir=\"ltr\" lang=\"es-CO\" class=\"has-object-object-font-size   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--44a8f82561216ec735a3b29027947863\"><strong>Referencias:<\/strong><br><br><strong>1. <\/strong>Roberts MB, Fishman JA. Immunosuppressive agents and infectious risk in transplantation: managing the \u201cnet stateof immunosuppression.\u201d Clin Infect Dis. 2021;73(7):e1302-e1317. doi:10.1093\/cid\/ciaa1189. <strong>2. <\/strong>Razonable RR, Humar A. Cytomegalovirus in solid organ transplant recipients\u2014Guidelines of the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transplant. 2019:33(9):13512. doi:10.1111\/ctr.13512. <strong>3. <\/strong>Limaye AP, Budde K, Humar A, et al. Letermovir vs valganciclovir for prophylaxis of cytomegalovirus in high-risk kidney transplant recipients: a randomized clinical trial. JAMA. 2023;330(1):33-42. doi:10.1001\/jama.2023.9106. <strong>4.<\/strong> Budde K, Kamar N, Crespo M, et al. Letermovir vs valganciclovir prophylaxis and risk of cytomegalovirus DNAemia in a randomized phase 3 trial. Poster presented at: European Society for Organ Transplantation (ESOT) Congress: September 17-20, 2023. <strong>5. <\/strong>Limaye AP, Budde K, Humar A, et al. Letermovir vs valganciclovir for prophylaxis of cytomegalovirus in high-risk kidney transplant recipients: a randomized clinical trial. JAMA. 2023;330(1):33-42. Supplement 2:1-13. doi:10.1001\/jama.2023.9106. 6. Prevymis Informaci\u00f3n para prescribir. Rep\u00fablica Dominicana.<\/p>\n\n\n<div class=\"mhh-mcn-columns mhh-mcn-v1-columns--663f0db79f2a582d1c481ca418aaac9a mhh-mcn-v1-columns mhh-mcn-columns--gutter-m\">\n    <div class=\"mhh-mcn-columns-inner\">\n        \n<div class=\"mhh-mcn-v1-column mhh-mcn-v1-column--c28977bffb6d32a4aacba4a0aa8ad954 mhh-mcn-column mhh-mcn-column--12 mhh-mcn-column--m-6 mhh-mcn-column--l-6\">\n    \n<figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--bb04550732812529a75250351984fffa\">\n                    <img decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--full wp-image-92073\"\n        src=\"https:\/\/msdconecta.co.cr\/es\/wp-content\/uploads\/sites\/77\/2024\/08\/prevymis_c7ed25.png?quality=80&#038;lossy=1\"\n        width=\"328\"\n        height=\"156\"\n        loading=\"lazy\"        alt=\"\"\n            \/>\n            <\/figure>\n\n<\/div>\n\n\n<div class=\"mhh-mcn-v1-column mhh-mcn-v1-column--fc60ed4e1def2acae456494c893d0508 mhh-mcn-column mhh-mcn-column--12 mhh-mcn-column--m-6 mhh-mcn-column--l-6\">\n    <\/div>\n\n    <\/div>\n\n    <\/div>\n\n\n<div class=\"mhh-mcn-v1-content-items mhh-mcn-v1-content-items--af53a832990057f28b24a17bcc3e2dc2 wp-block-mconnect-theme-curated-content mhh-mcn-layout--columns mhh-mcn-columns mhh-mcn-v1-columns--9031d28f7423572e853f6112c12fff1d mhh-mcn-v1-columns mhh-mcn-columns--gutter-m\" dir=\"ltr\" lang=\"es-CO\">\n    <div class=\"mhh-mcn-columns-inner\">\n        <div\n    class=\"mhh-mcn-column mhh-mcn-column--12 mhh-mcn-column--m-6 mhh-mcn-column--l-6 mhh-mcn-v1-content-item mhh-mcn-v1-content-item--37a4120a6b68b947ac7a975d55d68699 mhh-mcn-v1-content-item--card-style mhh-mcn-v1-content-item--no-media\" dir=\"ltr\" lang=\"es-CO\">\n    <article class=\"mhh-mcn-v1-content-item-content\">\n    <section class=\"mhh-mcn-v1-content-item-content-body\">\n        \n<span class=\"mhh-mcn-v1-content-item-primary-tag mhh-mcn-v1-content-item-primary-tag--c06ec76831703497d2b89abb588910eb\" title=\"This item has been tagged as: Recursos para descarga\">\n    Recursos para descarga<\/span>\n        <header class=\"mhh-mcn-v1-content-item-header\">\n    \n    <span class=\"mhh-mcn-v1-content-item-icon-type\">\n    <span class=\"mhh-mcn-v1-content-item-icon-type__icon\">\n    \n<svg width=\"1em\" height=\"1em\" class=\"mh-icon mh-icon--kind-generic mh-icon--name-arrow-right mh-icon--arrow-right\" role=\"img\" aria-hidden=\"true\">\n    \n    \n    <use xlink:href=\"https:\/\/msdconecta.co.cr\/es\/wp-content\/themes\/cex-wpvip-mhh-mconnect-theme-new-3.0\/modules\/icons\/resources\/icons\/svg\/generic\/arrow-right.svg#arrow-right\"><\/use>\n<\/svg>\n    <\/span>\n    <\/span>\n    <h2 class=\"mhh-mcn-v1-content-item-title mhh-mcn-v1-content-item-title--c06ec76831703497d2b89abb588910eb\">\n    \n    <a class=\"mhh-mcn-v1-content-item-title__link\" href=\"https:\/\/msdconecta.co.cr\/es\/therapeutic-areas\/antibioticos\/informacion-para-prescribir-prevymis-wp-0605\/\" target=\"_self\">\n        Informaci\u00f3n para Prescribir Prevymis\u00ae    <\/a>\n    <\/h2>\n\n    <\/header>\n\n                    <\/section>\n    <div class=\"mhh-mcn-v1-content-item-footer\">\n    \n    \n    <\/div>\n<\/article>\n<\/div>\n<div\n    class=\"mhh-mcn-column mhh-mcn-column--12 mhh-mcn-column--m-6 mhh-mcn-column--l-6 mhh-mcn-v1-content-item mhh-mcn-v1-content-item--ffc8a27b82818a3cce9678fc13d61f82 mhh-mcn-v1-content-item--card-style mhh-mcn-v1-content-item--no-media\" dir=\"ltr\" lang=\"es-CO\">\n    <article class=\"mhh-mcn-v1-content-item-content\">\n    <section class=\"mhh-mcn-v1-content-item-content-body\">\n        \n<span class=\"mhh-mcn-v1-content-item-primary-tag mhh-mcn-v1-content-item-primary-tag--c06ec76831703497d2b89abb588910eb\" title=\"This item has been tagged as: Recursos para descarga\">\n    Recursos para descarga<\/span>\n        <header class=\"mhh-mcn-v1-content-item-header\">\n    \n    <span class=\"mhh-mcn-v1-content-item-icon-type\">\n    <span class=\"mhh-mcn-v1-content-item-icon-type__icon\">\n    \n<svg width=\"1em\" height=\"1em\" class=\"mh-icon mh-icon--kind-generic mh-icon--name-arrow-right mh-icon--arrow-right\" role=\"img\" aria-hidden=\"true\">\n    \n    \n    <use xlink:href=\"https:\/\/msdconecta.co.cr\/es\/wp-content\/themes\/cex-wpvip-mhh-mconnect-theme-new-3.0\/modules\/icons\/resources\/icons\/svg\/generic\/arrow-right.svg#arrow-right\"><\/use>\n<\/svg>\n    <\/span>\n    <\/span>\n    <h2 class=\"mhh-mcn-v1-content-item-title mhh-mcn-v1-content-item-title--c06ec76831703497d2b89abb588910eb\">\n    \n    <a class=\"mhh-mcn-v1-content-item-title__link\" href=\"https:\/\/msdconecta.co.cr\/es\/therapeutic-areas\/antibioticos\/informacion-seleccionada-de-seguridad-prevymis-wp-0619\/\" target=\"_self\">\n        Informaci\u00f3n Seleccionada de Seguridad Prevymis\u00ae \n      <\/a>\n    <\/h2>\n\n    <\/header>\n\n                    <\/section>\n    <div class=\"mhh-mcn-v1-content-item-footer\">\n    \n    \n    <\/div>\n<\/article>\n<\/div>\n    <\/div>\n\n    <\/div>\n\n<\/div>\n\n    <\/div>\n\n    <\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":61360,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_mhh_mcn_text_direction":"ltr","_mhh_mcn_language":"es_CO","_mhh_mcn_left_sidebar_settings":{"entityId":0},"_mhh_mcn_sidebar_settings":{"entityId":0},"mhh_mcn_side_navigation_style":{"fontSize":{"l":"","m":"","s":""},"lineHeight":{"l":1.5,"m":1.5,"s":1.5},"itemColor":"","hoverItemColor":"","currentItemColor":"","borderItemColor":"","backgroundItemHoverColor":"","themeColor":""},"_mhh_mcn_child_page_navigation":{"isActive":false,"isSticky":false},"hide_header":false,"show_top_bar":false,"hide_footer":false,"full_width_layout":false,"icon":null,"job_code":"","primary_tag":0,"editor_notices":[],"mconnectHideShareThis":false,"footnotes":"","mconnectIsArchiveTemplate":false,"mconnectArchiveFiltersDisabled":false,"mconnectArchiveLockAllPresetFilters":false,"mconnectArchiveHidePageSubmenu":false,"mconnectArchiveShowParentPageOnly":false,"mconnectArchiveDefaultOrder":"DESC","mconnectArchiveDefaultOrderBy":"date","mconnectArchivePostsPerPage":12,"mconnectArchivePostTypes":[],"mconnectArchiveAllowFilterBy":["category","tx-content-type","tx-product","tx-pathology","tx-active-ingredient","tx-therapeutic-area"],"mconnectArchiveTaxonomyOrder":[],"mconnectArchiveFilterSorting":["is_keyword"],"mconnectArchiveContentItemStyle":{"showExcerpt":true,"showImage":true,"showIcon":false,"showPrimaryTag":true,"showBorder":false,"showDates":false,"showCta":true,"isCard":false,"hasBackground":false,"showMetadata":true},"mconnectArchiveLayout":{"type":"list","hasFeatured":false},"mconnectDynamicTaxonomyEntities":[],"mconnectArchiveTerms_category":[],"mconnectArchiveAllowTerms_category":[],"mconnectArchiveTerms_tx-content-type":[],"mconnectArchiveAllowTerms_tx-content-type":[],"mconnectArchiveTerms_tx-product":[],"mconnectArchiveAllowTerms_tx-product":[],"mconnectArchiveTerms_tx-pathology":[],"mconnectArchiveAllowTerms_tx-pathology":[],"mconnectArchiveTerms_tx-active-ingredient":[],"mconnectArchiveAllowTerms_tx-active-ingredient":[],"mconnectArchiveTerms_tx-therapeutic-area":[],"mconnectArchiveAllowTerms_tx-therapeutic-area":[],"mconnectArchiveAllowTerms_dynamic-taxonomy":[],"mconnectArchiveLegacyDefaultTermsApplied":false,"mconnectContentUpdatesPerPage":10,"mconnectContentUpdatesViewMoreUrl":"","mconnectContentUpdatesTerms_tx-content-type":[],"mconnectContentUpdatesTerms_tx-product":[],"mconnectContentUpdatesTerms_tx-pathology":[],"mconnectContentUpdatesTerms_tx-active-ingredient":[],"mconnectContentUpdatesTerms_tx-therapeutic-area":[],"sidebar_toogle":0,"sidebar_toogle_notification_warning":true,"sidebar_toogle_notification_alert":true,"content_expiration_sidebar_date":"","content_expiration_sidebar_expired_post_status":"","content_expiration_sidebar_redirection":""},"categories":[],"tags":[],"ga4_page_audience":[1187],"ga4_page_birn_id":[],"ga4_page_branding":[],"ga4_page_businessunit":[],"ga4_page_campaign":[],"ga4_page_content_purpose":[],"ga4_page_customer_journey_stage":[],"ga4_page_customer_specialty":[],"ga4_page_experience":[],"ga4_page_indication":[],"ga4_page_material_intent":[],"ga4_page_product":[],"ga4_page_region":[921],"ga4_page_therapeuticarea":[],"tx-therapeutic-area":[],"tx-product":[],"tx-pathology":[],"tx-content-type":[],"tx-active-ingredient":[],"mhh-area-of-interest":[],"access":[],"user_status":[],"user_role":[],"class_list":["post-92007","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Prevenci\u00f3n de la enfermedadpor CMV en receptores de trasplantede ri\u00f1\u00f3n D+\/R- de alto riesgo - MConnect Cenca Spanish<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/msdconecta.co.cr\/es\/prevencion-de-la-enfermedadpor-cmv-en-receptores-de-trasplantede-rinon-d-r-de-alto-riesgo-wp-0679\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Prevenci\u00f3n de la enfermedadpor CMV en receptores de trasplantede ri\u00f1\u00f3n D+\/R- de alto riesgo - MConnect Cenca Spanish\" \/>\n<meta property=\"og:url\" content=\"https:\/\/msdconecta.co.cr\/es\/prevencion-de-la-enfermedadpor-cmv-en-receptores-de-trasplantede-rinon-d-r-de-alto-riesgo-wp-0679\/\" \/>\n<meta property=\"og:site_name\" content=\"MConnect Cenca Spanish\" \/>\n<meta property=\"article:modified_time\" content=\"2024-09-05T16:06:29+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/msdconecta.co.cr\/es\/prevencion-de-la-enfermedadpor-cmv-en-receptores-de-trasplantede-rinon-d-r-de-alto-riesgo-wp-0679\/\",\"url\":\"https:\/\/msdconecta.co.cr\/es\/prevencion-de-la-enfermedadpor-cmv-en-receptores-de-trasplantede-rinon-d-r-de-alto-riesgo-wp-0679\/\",\"name\":\"Prevenci\u00f3n de la enfermedadpor CMV en receptores de trasplantede ri\u00f1\u00f3n D+\/R- de alto riesgo - MConnect Cenca Spanish\",\"isPartOf\":{\"@id\":\"https:\/\/msdconecta.co.cr\/es\/#website\"},\"datePublished\":\"2024-08-21T11:32:04+00:00\",\"dateModified\":\"2024-09-05T16:06:29+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/msdconecta.co.cr\/es\/prevencion-de-la-enfermedadpor-cmv-en-receptores-de-trasplantede-rinon-d-r-de-alto-riesgo-wp-0679\/#breadcrumb\"},\"inLanguage\":\"es-CO\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/msdconecta.co.cr\/es\/prevencion-de-la-enfermedadpor-cmv-en-receptores-de-trasplantede-rinon-d-r-de-alto-riesgo-wp-0679\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/msdconecta.co.cr\/es\/prevencion-de-la-enfermedadpor-cmv-en-receptores-de-trasplantede-rinon-d-r-de-alto-riesgo-wp-0679\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/msdconecta.co.cr\/es\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Prevenci\u00f3n de la enfermedadpor CMV en receptores de trasplantede ri\u00f1\u00f3n D+\/R- de alto riesgo\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/msdconecta.co.cr\/es\/#website\",\"url\":\"https:\/\/msdconecta.co.cr\/es\/\",\"name\":\"MConnect Cenca Spanish\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/msdconecta.co.cr\/es\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/msdconecta.co.cr\/es\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"es-CO\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/msdconecta.co.cr\/es\/#organization\",\"name\":\"MConnect Cenca Spanish\",\"url\":\"https:\/\/msdconecta.co.cr\/es\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es-CO\",\"@id\":\"https:\/\/msdconecta.co.cr\/es\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/msdconecta.co.cr\/es\/wp-content\/uploads\/sites\/77\/2022\/07\/logo_tcm2359-1256911.png\",\"contentUrl\":\"https:\/\/msdconecta.co.cr\/es\/wp-content\/uploads\/sites\/77\/2022\/07\/logo_tcm2359-1256911.png\",\"width\":152,\"height\":48,\"caption\":\"MConnect Cenca Spanish\"},\"image\":{\"@id\":\"https:\/\/msdconecta.co.cr\/es\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Prevenci\u00f3n de la enfermedadpor CMV en receptores de trasplantede ri\u00f1\u00f3n D+\/R- de alto riesgo - MConnect Cenca Spanish","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/msdconecta.co.cr\/es\/prevencion-de-la-enfermedadpor-cmv-en-receptores-de-trasplantede-rinon-d-r-de-alto-riesgo-wp-0679\/","og_locale":"es_ES","og_type":"article","og_title":"Prevenci\u00f3n de la enfermedadpor CMV en receptores de trasplantede ri\u00f1\u00f3n D+\/R- de alto riesgo - MConnect Cenca Spanish","og_url":"https:\/\/msdconecta.co.cr\/es\/prevencion-de-la-enfermedadpor-cmv-en-receptores-de-trasplantede-rinon-d-r-de-alto-riesgo-wp-0679\/","og_site_name":"MConnect Cenca Spanish","article_modified_time":"2024-09-05T16:06:29+00:00","twitter_card":"summary_large_image","twitter_misc":{"Tiempo de lectura":"3 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/msdconecta.co.cr\/es\/prevencion-de-la-enfermedadpor-cmv-en-receptores-de-trasplantede-rinon-d-r-de-alto-riesgo-wp-0679\/","url":"https:\/\/msdconecta.co.cr\/es\/prevencion-de-la-enfermedadpor-cmv-en-receptores-de-trasplantede-rinon-d-r-de-alto-riesgo-wp-0679\/","name":"Prevenci\u00f3n de la enfermedadpor CMV en receptores de trasplantede ri\u00f1\u00f3n D+\/R- de alto riesgo - MConnect Cenca Spanish","isPartOf":{"@id":"https:\/\/msdconecta.co.cr\/es\/#website"},"datePublished":"2024-08-21T11:32:04+00:00","dateModified":"2024-09-05T16:06:29+00:00","breadcrumb":{"@id":"https:\/\/msdconecta.co.cr\/es\/prevencion-de-la-enfermedadpor-cmv-en-receptores-de-trasplantede-rinon-d-r-de-alto-riesgo-wp-0679\/#breadcrumb"},"inLanguage":"es-CO","potentialAction":[{"@type":"ReadAction","target":["https:\/\/msdconecta.co.cr\/es\/prevencion-de-la-enfermedadpor-cmv-en-receptores-de-trasplantede-rinon-d-r-de-alto-riesgo-wp-0679\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/msdconecta.co.cr\/es\/prevencion-de-la-enfermedadpor-cmv-en-receptores-de-trasplantede-rinon-d-r-de-alto-riesgo-wp-0679\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/msdconecta.co.cr\/es\/"},{"@type":"ListItem","position":2,"name":"Prevenci\u00f3n de la enfermedadpor CMV en receptores de trasplantede ri\u00f1\u00f3n D+\/R- de alto riesgo"}]},{"@type":"WebSite","@id":"https:\/\/msdconecta.co.cr\/es\/#website","url":"https:\/\/msdconecta.co.cr\/es\/","name":"MConnect Cenca Spanish","description":"","publisher":{"@id":"https:\/\/msdconecta.co.cr\/es\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/msdconecta.co.cr\/es\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"es-CO"},{"@type":"Organization","@id":"https:\/\/msdconecta.co.cr\/es\/#organization","name":"MConnect Cenca Spanish","url":"https:\/\/msdconecta.co.cr\/es\/","logo":{"@type":"ImageObject","inLanguage":"es-CO","@id":"https:\/\/msdconecta.co.cr\/es\/#\/schema\/logo\/image\/","url":"https:\/\/msdconecta.co.cr\/es\/wp-content\/uploads\/sites\/77\/2022\/07\/logo_tcm2359-1256911.png","contentUrl":"https:\/\/msdconecta.co.cr\/es\/wp-content\/uploads\/sites\/77\/2022\/07\/logo_tcm2359-1256911.png","width":152,"height":48,"caption":"MConnect Cenca Spanish"},"image":{"@id":"https:\/\/msdconecta.co.cr\/es\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/msdconecta.co.cr\/es\/wp-json\/wp\/v2\/pages\/92007","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/msdconecta.co.cr\/es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/msdconecta.co.cr\/es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/msdconecta.co.cr\/es\/wp-json\/wp\/v2\/users\/61360"}],"replies":[{"embeddable":true,"href":"https:\/\/msdconecta.co.cr\/es\/wp-json\/wp\/v2\/comments?post=92007"}],"version-history":[{"count":46,"href":"https:\/\/msdconecta.co.cr\/es\/wp-json\/wp\/v2\/pages\/92007\/revisions"}],"predecessor-version":[{"id":92089,"href":"https:\/\/msdconecta.co.cr\/es\/wp-json\/wp\/v2\/pages\/92007\/revisions\/92089"}],"wp:attachment":[{"href":"https:\/\/msdconecta.co.cr\/es\/wp-json\/wp\/v2\/media?parent=92007"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/msdconecta.co.cr\/es\/wp-json\/wp\/v2\/categories?post=92007"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/msdconecta.co.cr\/es\/wp-json\/wp\/v2\/tags?post=92007"},{"taxonomy":"ga4_page_audience","embeddable":true,"href":"https:\/\/msdconecta.co.cr\/es\/wp-json\/wp\/v2\/ga4_page_audience?post=92007"},{"taxonomy":"ga4_page_birn_id","embeddable":true,"href":"https:\/\/msdconecta.co.cr\/es\/wp-json\/wp\/v2\/ga4_page_birn_id?post=92007"},{"taxonomy":"ga4_page_branding","embeddable":true,"href":"https:\/\/msdconecta.co.cr\/es\/wp-json\/wp\/v2\/ga4_page_branding?post=92007"},{"taxonomy":"ga4_page_businessunit","embeddable":true,"href":"https:\/\/msdconecta.co.cr\/es\/wp-json\/wp\/v2\/ga4_page_businessunit?post=92007"},{"taxonomy":"ga4_page_campaign","embeddable":true,"href":"https:\/\/msdconecta.co.cr\/es\/wp-json\/wp\/v2\/ga4_page_campaign?post=92007"},{"taxonomy":"ga4_page_content_purpose","embeddable":true,"href":"https:\/\/msdconecta.co.cr\/es\/wp-json\/wp\/v2\/ga4_page_content_purpose?post=92007"},{"taxonomy":"ga4_page_customer_journey_stage","embeddable":true,"href":"https:\/\/msdconecta.co.cr\/es\/wp-json\/wp\/v2\/ga4_page_customer_journey_stage?post=92007"},{"taxonomy":"ga4_page_customer_specialty","embeddable":true,"href":"https:\/\/msdconecta.co.cr\/es\/wp-json\/wp\/v2\/ga4_page_customer_specialty?post=92007"},{"taxonomy":"ga4_page_experience","embeddable":true,"href":"https:\/\/msdconecta.co.cr\/es\/wp-json\/wp\/v2\/ga4_page_experience?post=92007"},{"taxonomy":"ga4_page_indication","embeddable":true,"href":"https:\/\/msdconecta.co.cr\/es\/wp-json\/wp\/v2\/ga4_page_indication?post=92007"},{"taxonomy":"ga4_page_material_intent","embeddable":true,"href":"https:\/\/msdconecta.co.cr\/es\/wp-json\/wp\/v2\/ga4_page_material_intent?post=92007"},{"taxonomy":"ga4_page_product","embeddable":true,"href":"https:\/\/msdconecta.co.cr\/es\/wp-json\/wp\/v2\/ga4_page_product?post=92007"},{"taxonomy":"ga4_page_region","embeddable":true,"href":"https:\/\/msdconecta.co.cr\/es\/wp-json\/wp\/v2\/ga4_page_region?post=92007"},{"taxonomy":"ga4_page_therapeuticarea","embeddable":true,"href":"https:\/\/msdconecta.co.cr\/es\/wp-json\/wp\/v2\/ga4_page_therapeuticarea?post=92007"},{"taxonomy":"tx-therapeutic-area","embeddable":true,"href":"https:\/\/msdconecta.co.cr\/es\/wp-json\/wp\/v2\/tx-therapeutic-area?post=92007"},{"taxonomy":"tx-product","embeddable":true,"href":"https:\/\/msdconecta.co.cr\/es\/wp-json\/wp\/v2\/tx-product?post=92007"},{"taxonomy":"tx-pathology","embeddable":true,"href":"https:\/\/msdconecta.co.cr\/es\/wp-json\/wp\/v2\/tx-pathology?post=92007"},{"taxonomy":"tx-content-type","embeddable":true,"href":"https:\/\/msdconecta.co.cr\/es\/wp-json\/wp\/v2\/tx-content-type?post=92007"},{"taxonomy":"tx-active-ingredient","embeddable":true,"href":"https:\/\/msdconecta.co.cr\/es\/wp-json\/wp\/v2\/tx-active-ingredient?post=92007"},{"taxonomy":"mhh-area-of-interest","embeddable":true,"href":"https:\/\/msdconecta.co.cr\/es\/wp-json\/wp\/v2\/mhh-area-of-interest?post=92007"},{"taxonomy":"access","embeddable":true,"href":"https:\/\/msdconecta.co.cr\/es\/wp-json\/wp\/v2\/access?post=92007"},{"taxonomy":"user_status","embeddable":true,"href":"https:\/\/msdconecta.co.cr\/es\/wp-json\/wp\/v2\/user_status?post=92007"},{"taxonomy":"user_role","embeddable":true,"href":"https:\/\/msdconecta.co.cr\/es\/wp-json\/wp\/v2\/user_role?post=92007"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}