{"id":88365,"date":"2024-03-12T12:47:22","date_gmt":"2024-03-12T12:47:22","guid":{"rendered":"https:\/\/msdconecta.co.cr\/es\/?post_type=product&p=88365"},"modified":"2024-03-13T11:50:06","modified_gmt":"2024-03-13T11:50:06","slug":"eficacia-de-la-vacuna","status":"publish","type":"product","link":"https:\/\/msdconecta.co.cr\/es\/products\/pneumovax\/eficacia-de-la-vacuna\/","title":{"rendered":"Eficacia de la vacuna"},"content":{"rendered":"\n

Conozca la eficacia de PNEUMOVAX 23 y proteja a sus pacientes contra la infecci\u00f3n neumoc\u00f3cica invasiva<\/strong><\/h2>\n\n\n
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Seg\u00fan el estudio de cohortes indirecto retrospectivo de Butler, JC. y colsa<\/sup><\/em>, que abarc\u00f3 un periodo de 14 a\u00f1os, con una muestra de 2,837 personas mayores de 5 a\u00f1os de edad y que presentaron enfermedad neumoc\u00f3cica invasiva con aislamiento de neumococo en sangre o en LCR, se mostr\u00f3 que PNEUMOVAX 23 previno efectivamente ENI debido a los serotipos incluidos en ella, con una eficacia general estimada en 60%.1<\/sup><\/strong><\/p>\n\n<\/div>\n\n\n

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Se confirm\u00f3 la eficacia de la vacuna en pacientes con diabetes (84%)<\/strong>, enfermedad vascular coronaria (73%)<\/strong>, insuficiencia cardiaca congestiva (69%)<\/strong>, enfermedad pulmonar cr\u00f3nica (65%)<\/strong>, asplenia anat\u00f3mica (77%)<\/strong> y en personas inmunocompetentes mayores de 65 a\u00f1os (75%)<\/strong>. No se demostr\u00f3 eficacia en pacientes con alcoholismo o cirrosis (0%)<\/strong>, en pacientes con leucemia ni con mieloma m\u00faltiple. Se observ\u00f3 que estos anticuerpos declinaron r\u00e1pida o lentamente en pacientes con anemia falciforme, enfermedad renal cr\u00f3nica, enfermedad de Hodgkin y mieloma m\u00faltiple.1<\/sup> <\/p>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n\n\n

a<\/sup>ESTUDIO BUTTLER, JC. Y COLS. Estudio de cohortes, indirecto, retrospectivo, en EUA que abarc\u00f3 un periodo de 14 a\u00f1os (1978 a 1992) en 54 hospitales y 26 estados. Los pacientes elegibles para la inclusi\u00f3n ten\u00edan \u22652 a\u00f1os de edad con un estado\/fecha de vacunaci\u00f3n conocida, que fueron monitoreados por enfermedad durante este periodo, y de quienes se aisl\u00f3 el neumococo de la sangre o del l\u00edquido cefalorraqu\u00eddeo (LCR). La mediana de edad de los pacientes vacunados fue de 57 a\u00f1os; la mediana de edad de los no vacunados fue de 50 a\u00f1os. La eficacia de la vacuna se estim\u00f3 comparando la distribuci\u00f3n de los serotipos neumoc\u00f3cicos que causan la enfermedad en los vacunados (ej.,recibieron las vacunas de polisac\u00e1ridos antineumoc\u00f3cicos de 14 serotipos o 23 serotipos) y personas no vacunadas. La eficacia de la vacuna tambi\u00e9n se estim\u00f3 para los participantes del estudio con enfermedades ubyacente.1<\/sup><\/em><\/p>\n\n\n\n

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Referencia:<\/p>\n\n\n\n

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  1. Butler JC, Breiman RF, Campbell JF, y cols. Pneumococcal polysaccharide vaccine efficacy: an evaluation of current recommendations. JAMA. 1993; 270 (15):1826\u20131831.<\/span><\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"

    Conozca la eficacia de PNEUMOVAX 23 y proteja a sus pacientes contra la infecci\u00f3n neumoc\u00f3cica invasiva aESTUDIO BUTTLER, JC. 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